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TB-500 is one of the most significant synthetic research peptides in regenerative and cellular biology studies. It is the -terminally acetylated synthetic fragment () that mimics the central, highly active domain () of the naturally occurring 43-amino-acid protein, Thymosin Beta-4 () [1, 2].
The core research utility of TB-500 lies in its fundamental role as an actin regulator, making it invaluable for labs studying cellular structure, motility, and tissue repair mechanisms.
This guide details TB-500’s unique molecular function, its key applications in research, and the strict compliance standards required for its procurement in Canada.
TB-500’s mechanism is distinct from other regulatory peptides, focusing on the cytoskeleton—the internal scaffolding of the cell.
The primary function of and its analog, TB-500, is to bind to monomeric G-actin (globular actin) [1, 2].
Action: This actin-sequestering property prevents G-actin monomers from polymerizing into F-actin (filamentous actin), essentially maintaining a pool of free G-actin within the cell [2].
Research Relevance: The controlled release of G-actin from TB-500/ triggers rapid actin polymerization, which is the mechanical force driving cellular motility and structural changes [2.5, 3.4].
By regulating the actin cytoskeleton, TB-500 acts as a potent inducer of cellular migration, a critical step in tissue repair [1, 2].
Wound Healing Models: It facilitates the movement of key repair cells (like keratinocytes and fibroblasts) to injury sites [1.4].
Angiogenesis: TB-500 is intensely researched for its ability to promote angiogenesis (the formation of new blood vessels) by stimulating the migration and differentiation of endothelial cells [1.5, 3.2]. This process is crucial for supplying oxygen and nutrients to damaged or regenerating tissue.
Given that injectable peptides are frequently flagged by Health Canada as unauthorized prescription drugs when intended for human use, strict Research-Use-Only (RUO) compliance is mandatory [4.3, 4.4].
Analytical Standard: Luxara Labs supplies TB-500 with analytical purity, verified by HPLC and Mass Spectrometry (MS).
Documentation: A lot-specific Certificate of Analysis (COA) must accompany every batch, providing full transparency on identity () and concentration.
Legal Use: TB-500 is legal to procure and use only for controlled, in-vitro, scientific, and laboratory experiments.
Prohibition: It is NOT a therapeutic agent, drug, or supplement and is prohibited for human or animal use in Canada.
A batch-specific COA for TB-500 should list:
Researchers depend on this documentation for experimental reproducibility.
Most peptide suppliers in Canada ship via:
Typical Canadian delivery time:
📦 1–2 business days
Domestic shipping advantages:
Permitted research applications include:
✔ in-vitro biochemical testing
✔ cell-based models
✔ molecular pathway studies
✔ cytoskeleton investigations
✔ receptor binding assays
✔ stability profiling
Not permitted:
❌ human use
❌ animal use
❌ therapeutic claims
❌ dosing instructions
All research involving TB-500 in Canada must follow research-only guidelines.
Canadian researchers avoid suppliers that:
A reliable supplier prioritizes transparency and clarity.
Researchers repeatedly cite:
Domestic sourcing also removes the uncertainty of international customs delays.
Yes — for research, laboratory, and in-vitro use only.
No. It requires a legitimate research purpose, not a medical prescription.
No. TB-500 is not approved for therapeutic use.
Canadian labs typically use ≥99% purity.
Most orders arrive in 1–2 business days within Canada.
All information is for scientific and laboratory reference.
TB-500 referenced here is strictly for research, laboratory, and in-vitro use only — not for human or animal use.
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