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High-Purity Mitochondrial Peptide for Canada

 

 

SS-31 (ELAMIPRETIDE) MITOCHONDRIA-TARGETED RESEARCH GUIDE — CANADA (2025–2026)

 

Overview: The Mitochondria-Targeted Tetrapeptide

SS-31 (also known in scientific literature as Elamipretide) is a synthetic, mitochondria-targeted research peptide that has gained significant attention among Canadian researchers. Unlike most peptides that act on cell surface receptors, SS-31’s unique structure allows it to accumulate rapidly and specifically on the inner mitochondrial membrane () [1, 2].

Its stability, purity, and predictable behaviour make it a valuable tool in cellular bioenergetics, oxidative stress modelling, and mitochondrial pathway studies. SS-31 is a cornerstone for labs exploring dysfunction related to energy, stress, and structural pathways.

This 2025–2026 guide provides Canadian researchers with:

  • A clear scientific overview of SS-31
  • Common research applications
  • Purity expectations (≥99%)
  • COA requirements
  • Domestic shipping advantages
  • Canadian research-use regulations
  • What to look for in a supplier
  • How SS-31 fits into mitochondrial research clusters (MOTS-C, NAD+, etc.)

All details here are strictly for scientific, laboratory, and in-vitro research.
Not for human or animal use.


What Is SS-31?

(Mechanism of Action)

SS-31 is a small, linear tetrapeptide with the sequence [3]. Its structure gives it a net positive charge which is the critical feature that drives its targeting [1.4, 3.3].

The Cardiolipin Pathway

The core mechanism of SS-31 is its high-affinity interaction with the phospholipid Cardiolipin ().

  • CL Localization: Cardiolipin is unique because it is almost exclusively found on the Inner Mitochondrial Membrane () [1.1].

  • CL Function: is essential for organizing the protein complexes of the Electron Transport Chain () into supercomplexes [1.3]. Oxidative stress can peroxidize (damage) , leading to disorganization and increased Reactive Oxygen Species () production [2.3].

  • SS-31 Action: SS-31 is hypothesized to stabilize structure, preventing its peroxidation and maintaining the optimal organization of the [1.4].

This mechanism allows researchers to study the immediate effects of boosting ATP and bioenergetic signalling frameworks and reducing at the source, rather than just scavenging after it has formed.


    Why SS-31 Is Popular in Canadian Research (2025–2026)

    Canadian laboratories use SS-31 because:

    ✔ It has consistent in-vitro behaviour

    ✔ It supports high-value mitochondrial research

    ✔ It pairs well with MOTS-C studies

    ✔ It complements NAD+ and metabolic assays

    ✔ It is structurally stable in freeze-dried form

    ✔ It is easy to incorporate into cell-based and biochemical models

    SS-31 is part of a growing mitochondrial peptide cluster that includes:

    • MOTS-C
    • Humanin (HNG)
    • SS-31 analogues
    • NAD+ pathway modelling

    This makes it a core peptide for labs exploring energy, stress, and structural pathways.


    Purity Expectations for SS-31 (≥99% Standard)

    As with all peptides used in Canadian labs:

    ✔ ≥99% purity (HPLC-verified)

    ✔ Batch-specific COA

    ✔ Mass spectrometry identity confirmation

    ✔ Proper lyophilization (uniform cake)

    ✔ Clean, accurate labeling

    Purity matters because mitochondrial research relies heavily on precision and reproducibility.


    What a Proper SS-31 COA Should Include

    A compliant COA should list:

    • HPLC purity (%)
    • MS molecular weight confirmation
    • Batch or lot number
    • Testing date
    • Lab verification identifier
    • Structural integrity confirmation

    Researchers rely on COAs for consistent, repeatable experiments.


    How SS-31 Is Shipped Within Canada

    Most Canadian suppliers use:

    • UPS Express
    • FedEx Priority
    • Purolator Express
    • Xpresspost

    Delivery times:

    📦 1–2 business days Canada-wide.

    Domestic shipping provides:

    • no customs delays
    • lower temperature fluctuation
    • faster transit
    • minimal handling
    • better reliability for sensitive materials

    How SS-31 Is Used in Canadian Labs (Research-Only)

    Permitted scientific applications include:

    ✔ in-vitro mitochondrial studies
    ✔ oxidative stress modelling
    ✔ cellular bioenergetic experiments
    ✔ biochemical signalling assays
    ✔ molecular pathway analysis
    ✔ structural lipid research

    Not permitted:

    ❌ human use
    ❌ animal use
    ❌ therapeutic suggestions
    ❌ dosing instructions
    ❌ medical claims

    All SS-31 usage in Canada must follow research-use-only rules.


    Red Flags When Evaluating SS-31 Suppliers

    Canadian researchers avoid suppliers who:

    • do not offer COAs
    • use generic non-batch-matched documents
    • ship internationally without notice
    • use unprofessional labeling
    • provide medical/therapeutic claims
    • lack transparency about fulfillment location
    • have inconsistent product photos

    Transparency is a core requirement in Canadian research.


    Why Canadian Researchers Prefer Domestic Suppliers

    Benefits include:

    • reliable purity and batch consistency
    • COA clarity
    • fast shipping
    • predictable inventory
    • proper lyophilization
    • professional packaging
    • easy communication and support

    Domestic sourcing avoids U.S. customs and temperature fluctuations.


    Frequently Asked Questions

    Is SS-31 legal to buy in Canada?

    Yes — strictly for in-vitro, laboratory, and scientific research.

    Does SS-31 require a prescription?

    No. It requires a legitimate research purpose, not medical authorization.

    Is SS-31 allowed for human use in Canada?

    No. It is not approved as a therapeutic product.

    What purity should SS-31 have?

    Canadian labs typically use ≥99% laboratory purity.

    How fast is shipping?

    Most domestic shipments arrive in 1–2 business days.


     

    🔬 Research References 

    [1] Contemporary insights into elamipretide’s mitochondrial mechanism of action and therapeutic effects. PubMed (2025).

    [2] Differential Effects of the Mitochondria-Active Tetrapeptide SS-31. Frontiers in Pharmacology (2019).

    [3] Elamipretide Improves Mitochondrial Function in the Failing Human Heart. J. Am. Heart Assoc. (2019).

    [4] Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects… in Spinal Cord Injury. MDPI (2024).

    [5] Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial. NIH (2023).

    [6] Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential. MDPI (2024).

     

    Related Research Guides


    Disclaimer

    All information is provided for scientific and laboratory reference only.
    SS-31 is intended strictly for research, laboratory, and in-vitro use, not for human or animal use.

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