PT-141 (Bremelanotide) Research Guide — Canada (2025–2026)
PT-141 (Bremelanotide) Research Guide — Canada (2025–2026)
What Is PT-141?
PT-141 (Bremelanotide) is a synthetic peptide derived from the melanocortin system, particularly targeting MC1R and MC4R receptors. [1, 2]
It has become one of the most studied peptides in behavioral, neurological, and melanocortin research models.
Unlike many pathways that act indirectly, PT-141 interacts directly with neural melanocortin receptors — making it valuable for labs studying:
- Central nervous system signaling
- Behavioral response pathways
- Melanocortin receptor selectivity
- Neuropeptide modulation
PT-141 is not a PDE-5 analogue and operates through a completely different research mechanism.
How PT-141 Works (Mechanistically)
Research models suggest PT-141 may influence:
1. MC4R Activation [1, 3]
A key melanocortin receptor involved in:
- CNS signaling
- Behavioral modulation
- Neural cascade activation
2. MC1R Activity
Associated with:
- Pigmentation modulation
- Melanocyte signaling
- Secondary pathways for neural response
3. Direct Neurological Pathway Engagement
PT-141 is of high interest in neuroscience labs because it interacts centrally, not peripherally.
This sets it apart from many other peptides and makes it valuable for research into:
- Neurochemical pathways
- Behavioral studies
- Melanocortin receptor mapping
Current Areas of Scientific Interest (Preclinical Only)
PT-141 appears in preclinical literature focused on:
- MC4R agonist behavior
- CNS research
- Melanocortin receptor signaling
- Neural pathway activation
All discussion remains strictly academic and preclinical.
Molecular Profile
| Property | Details |
|---|---|
| Peptide name | PT-141 (Bremelanotide) |
| Class | Melanocortin receptor peptide |
| CAS | 189691-06-3 |
| Sequence | Ac-Nle-c[Asp-His-DNal(2’)-Arg-Trp-Lys]-OH |
| Research targets | MC1R, MC4R |
Why PT-141 Is Popular in Canadian Research Labs
Researchers often choose PT-141 because:
- It acts directly on CNS melanocortin receptors
- It has a defined and well-mapped receptor profile
- It allows investigation of neural pathways
- It is widely referenced in preclinical behavioral studies
Its distinct mechanism makes it a unique candidate for receptor-level investigation.
Storage & Handling
- Store at –20°C for long-term stability
- Avoid repeated freeze–thaw cycles
- Reconstitute using sterile techniques
- Use only in controlled research environments
PT-141 vs. Kisspeptin (Quick Comparison)
| Feature | PT-141 | Kisspeptin |
|---|---|---|
| Primary receptors | MC1R / MC4R | GPR54 |
| Research category | Melanocortin | Hypothalamic |
| CNS involvement | Strong | Moderate |
| Pathway type | Direct receptor agonist | GnRH-linked modulation |
PT-141 is uniquely melanocortin-focused, making it valuable in neurological receptor research.
FAQ (Research-Focused)
Is PT-141 legal to purchase in Canada?
Yes — for research use only.
It is not for human use or medical applications.
Is it similar to PDE-5 analogs?
No.
PT-141 works through melanocortin receptors, not nitric-oxide or vascular pathways.
Who typically uses PT-141?
- Universities
- Private research labs
- Scientific teams mapping melanocortin pathways
🔬 Research References
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- BPC-157 Canada Guide – https://luxaralabs.com/bpc157-canada/
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