Peptide of the Week: GLOW and KLOW — 10% Off This Week
Peptide of the Week: GLOW and KLOW — 10% Off This Week
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the α-MSH (alpha-melanocyte–stimulating hormone) sequence.
It has gained significant attention in Canadian research circles due to its involvement in melanocortin-linked pathways, cellular signalling, and inflammation-modulation models. [1, 2]
KPV is commonly studied in:
This guide summarizes how KPV functions mechanistically, what pathways are being explored in published research, and how Canadian laboratories use it in controlled scientific settings.
KPV is a short, stable tripeptide sequence (Lysine-Proline-Valine) found at the carboxyl-terminus of the larger neurohormone -MSH.
Its small, simple structure provides distinct advantages for research:
Selectivity: It retains the anti-inflammatory capacity of the parent hormone without the full hormonal activity (e.g., pigmentation effects) associated with full -MSH receptor engagement [2, 3].
Cellular Uptake: Research shows KPV is actively transported into cells via the PepT1 (Peptide Transporter 1) mechanism, which is often upregulated in areas of inflammation (like the colon) [4]. This makes it an ideal probe for studying transport-mediated cellular effects.
KPV is believed to act on elements of the melanocortin system without the full receptor engagement seen in α-MSH, making it useful in studies that require selective signalling. [1, 5]
Preclinical models show KPV may modulate NF-κB–linked pathways, which are involved in:
Its selective activity is what makes it valuable for inflammation and immunology research. [3]
KPV is also frequently explored in:
This is why KPV appears often in dermatology and mucosal immunity studies. [4, 5]
KPV stands out because it is:
Canadian researchers value KPV for its clean molecular structure and predictable behaviour in controlled systems.
| Property | Details |
|---|---|
| Peptide Name | KPV |
| Sequence | Lys-Pro-Val |
| Derived From | C-terminal of α-MSH |
| Research Categories | Inflammation, melanocortin system, epithelial studies |
| CAS No. | 130213-82-0 |
Most Canadian labs expect:
Luxara Labs provides full transparency with COAs, batch data, and high-purity material — shipped from within Canada.
Yes — for research use only.
Not for human or veterinary use.
No.
KPV is valued precisely because it does not exhibit full receptor activation like α-MSH.
KPV from Luxara Labs is for scientific, laboratory, and in-vitro research only. No claims of safety, efficacy, or human use are made or implied.
Peptides in the United States
https://luxaralabs.com/peptides-usa/
An overview for US-based researchers explaining how research peptides are sourced from Canada, including documentation standards, quality verification, and cross-border considerations.
US Peptide Research Regulations
https://luxaralabs.com/peptide-research-regulations-usa/
A clear explanation of how research peptides are treated under US regulatory frameworks, including FDA oversight, import screening, labeling requirements, and compliance considerations.
Shipping Peptides to the USA
https://luxaralabs.com/shipping-peptides-to-usa/
A transparent guide outlining what US researchers can expect when shipping peptides from Canada, including customs review, delivery timelines, and potential shipment outcomes.
KPV (Lysine-Proline-Valine) is the C-terminal tripeptide fragment of Alpha-Melanocyte Stimulating Hormone (-MSH). While the full -MSH molecule influences pigmentation and appetite, the KPV fragment is the primary driver of its potent anti-inflammatory effects. In research, KPV is prized because it lacks the melanotropic (skin-darkening) properties of the full hormone, allowing for the study of pure immune modulation and tissue repair in laboratory models.
KPV’s most studied mechanism is the direct inhibition of the NF-B (Nuclear Factor-kappa B) pathway—a “master switch” for inflammation. By blocking this pathway, KPV prevents the production of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1$\beta$. Crucially, research shows that KPV is transported into cells via the PepT1 transporter, allowing it to work intracellularly to “calm” inflammatory signaling without suppressing the body’s overall ability to fight infection.
Beyond its anti-inflammatory role, KPV exhibits direct antimicrobial properties, particularly against pathogens like Staphylococcus aureus and Candida albicans. In gastrointestinal research, KPV is studied for its ability to strengthen “Tight Junctions,” the proteins that seal the intestinal lining. This makes it a leading subject for research into Leaky Gut Syndrome and inflammatory bowel conditions, where it aims to prevent the translocation of toxins into the systemic circulation.
KPV is a highly stable tripeptide, making it unique as it can be studied in oral, topical, or injectable forms. For long-term preservation of the lyophilized powder, it should be stored at -20°C. Once reconstituted with bacteriostatic water, the solution is stable for 3–4 weeks when refrigerated at 2-8°C. Because it is a short-chain peptide, it is less susceptible to mechanical shearing than longer chains (like GHRPs), but it should still be protected from UV light and high-pH environments.
Scientific precision in autoimmune and gut-health research requires zero synthesis byproducts. Luxara Labs ensures every batch of KPV undergoes 3rd-party HPLC and MS testing to verify 99% purity. We provide expedited shipping across Canada and the USA in vacuum-sealed, temperature-stable packaging. This ensures your research materials arrive in Ontario, BC, or any US state with their molecular integrity fully intact for reliable laboratory application.
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