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MOTS-C in Canada
MOTS-C is one of the fastest-growing research peptides in Canada thanks to its mitochondrial-based origins and increasing interest in metabolic and cellular laboratory studies.
Owing to its unique classification as a Mitochondrial-Derived Peptide (MDP). Unlike most peptides encoded by nuclear DNA, MOTS-c is encoded by a short open reading frame within the mitochondrial genome (12S rRNA), allowing it to act as a direct regulator of cellular energy balance [1, 2].
The peptide is an essential tool for Canadian research into metabolic homeostasis, insulin signaling, and exercise-mimetic pathways.
This guide details MOTS-c’s mechanism of action, its role as a metabolic regulator, and the sourcing standards required by Canadian researchers.
MOTS-c is a 16-amino acid peptide (sequence: MRWQEMGYIFYPRKLR). Its origin from the mitochondrial genome is highly significant because it facilitates a unique form of communication known as mitochondrial-nuclear cross-talk [2].
Retrograde Signaling: MOTS-c acts as a retrograde signaling molecule, transmitting information about the cell’s metabolic state from the mitochondria back to the nucleus to regulate the expression of nuclear genes related to stress and metabolism [1].
Cellular Location: MOTS-c is found in the cytosol, co-localizes to the mitochondria, and under metabolic stress, translocates to the nucleus to direct gene expression [2].
MOTS-c is often described in research as an “exercise-mimetic” agent because its core mechanism mirrors the cellular adaptations triggered by physical activity [3].
MOTS-c’s primary function is the activation of AMP-activated protein kinase (AMPK), often referred to as the cell’s metabolic master switch [1, 3].
Insulin Sensitivity: By activating AMPK, MOTS-c enhances the translocation of GLUT4 (Glucose transporter 4) to the cell surface, promoting glucose uptake and improving insulin sensitivity in skeletal muscle and fat tissue [4].
Fatty Acid Oxidation: AMPK activation also promotes the beta-oxidation of fatty acids (burning fat for energy), which helps reduce lipid accumulation and prevents the oxidative stress associated with excess lipids [1].
Studies suggest MOTS-c activates AMPK by interacting with the folate-methionine cycle within the cytosol. By disrupting this cycle, it can lead to the accumulation of endogenous AICAR, which is a known allosteric activator of AMPK [3].
MOTS-c regulates the expression of numerous nuclear genes involved in antioxidant defense, cellular stress response, and mitochondrial biogenesis [1, 4]. This metabolic reprogramming increases cellular resilience against metabolic damage, a key area of study in age-related decline [5].
MOTS-C is studied in:
Researchers often assess:
Canadian labs typically require:
High-purity MOTS-C ensures accuracy in pathway studies and controlled in-vitro environments.
In Canada, MOTS-C is classified under research-use-only guidelines, meaning:
This guide follows Canadian research-only compliance.
MOTS-C pricing varies depending on:
Canadian researchers typically prefer domestic suppliers for faster delivery and more stable peptide handling.
Choosing a Canadian supplier provides:
This is why Canadian labs overwhelmingly choose domestic MOTS-C suppliers.
Researchers in Canada usually look for suppliers offering:
For a full overview of peptide sourcing in Canada, you can reference:
👉 Peptides in Canada — 2025–2026 Research Guide
(/peptides-canada/)
All information is for scientific, educational, and laboratory reference only.
All peptides described are strictly for research, in-vitro, and scientific use, not for human or animal consumption.
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